Kreb's Citric Acid Cycle

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One Turn of the Cycle

Acetyl-CoA + 3 NAD+ + FAD + GDP + Pi + 3 H2O ---> 3 NADH + FADH2 + CoA-SH + GTP + 3 CO2

Acetyl-CoA
Oxaloacetate
Oxaloacetate		Citrate
Citrate
Malate
Malate		 Isocitrate
Isocitrate
 
Fumarate
Fumarate		 a-Ketoglutarate
a-Ketoglutarate
Succinate
Succinate		Succinyl-CoA
Succinyl-CoA


Gibbs Free Energy Changes

Rxn#EnzymeDG°'
(kJ/mol)		 DG
(kJ/mol)
1Citrate synthase -32.2
2Aconitase +6.3
3Isocitrate dehydrogenase -20.9
4a-Ketoglutarate dehydrogenase
complex		 -33.5
5Succinyl-CoA synthetase -2.9
6Succinate dehydrogenase 0.0
7Fumerase -3.8
8Malate dehydrogenase +29.7

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[The Metabolic Pathways of Biochemistry] - [Copyright © 1998 Karl J. Miller.]