Objectives: An overview of the principles, instrumentation, methods, and applications
of mass spectrometry and electrochemistry is provided. We work
toward the in-depth understanding of state-of-the-art methods
to explore their fundamentals and to appreciate how new methods
are developed. Discussions on typical applications of these techniques
highlight their role in solving biomedical, environmental, industrial,
and forensic problems.
Topics:
Mass Spectrometry
- Charged particles in electromagnetic
fields (vacuum)
- Vacuum systems (mean free path, pumps,
gauges)
- Ion sources (electron impact, chemical
ionization, field desorption, fast atom bombardment, plasma desorption,
laser desorption, electrospray, spark source, glow discharge)
- Analyzers (magnetic sector, quadrupole,
time of flight, ion cyclotron resonance, ion trap)
- Detectors (Faraday cup, electron
multiplier, multichannel plate)
- Data acquisition systems, computer
aided data evaluation (A/D and D/A converters, transient recorders,
digital oscilloscopes, spectrum manipulation, calibration, peak
finding)
- Design of ion optical elements (momentum
and energy filtering, spatial, time, and energy focusing, constrains,
SIMION)
- Analysis of inorganic components
in liquids and solids (sample introduction systems)
- Analysis and structure determination
of small organic components (fragmentation patterns, NIST/EPA/NIH
MS Library, tandem MS/MS techniques)
Electrochemistry
- Charged particles in electromagnetic
fields (solutions)
- Electrochemical cells (thermodynamic
properties, electrode potentials, interfacial region)
- Kinetics and mechanism of electrode
reactions (electron transfer, mass transport, diffusion control,
surface reactions, Tafel law)
- Potentiometry (glass electrode, ion
selective electrodes, ISFETs)
- Hydrodynamic electrodes (dropping
mercury, rotating disc, ring-disc, tube, and wall-jet electrodes)
- Voltammetry I: linear sweep and cycling
techniques
- Voltammetry II: step and pulse techniques
- Impedance methods
- Electrochemistry in industry (electrolysis,
electrodeposition, batteries, fuel cells, corrosion)
- Bioelectrochemistry
- Suggested readings: You are encouraged to read the following
journals on a regular basis.
Science
Analytical Chemistry
Journal of the American Society for Mass Spectrometry
Journal of the Electrochemical Society
Academic Integrity: This course is committed to uphold the standards
described in the Code of Academic Integrity. A
short introduction to the Code is enclosed. The complete Code
is available in the Guide to Student Rights and Responsibilities.
Prerequisites: A strong foundation in analytical chemistry and
permission of the instructor.
Grading: The
following components determine your final grade: Science article 10%, SIMION assignment 10%, classroom contributions 10%, presentation of article 20% and final exam 50%.
For more information call me or the
Chemistry Department at (202) 994-6121.
|
