Metabolic Pathways of Biochemistry - Glycolysis and Gluconeogenesis 3-D

	Glycolysis & Gluconeogenesis
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Overall Reaction for the Pathway
Glucose + 2 ADP + 2 P_i + 2 NAD⁺	`--->`	2 Pyruvate + 2 ATP + 2 NADH + 2 H⁺ + 2 H₂O

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a-D-Glucose

a-D-Glucose-6-phosphate

D-Fructose-6-phosphate

D-Fructose-1,6-bisphosphate

Glyceraldehyde-3-phosphate + Dihydroxyacetone phosphate

Glyceraldehyde-3-phosphate

1,3-Bisphosphoglycerate

3-Phosphoglycerate

2-Phosphoglycerate

Phosphoenolpyruvate

Pyruvate

Gibbs Free Energy Changes

Rxn#	Enzyme	DG°' (kJ/mol)	DG (kJ/mol)
1	Hexokinase	-16.7	-33.5
2	Phosphoglucoisomerase	+1.7	-2.5
3	Phosphofructokinase	-14.2	-22.2
4	Aldolase	+23.9	-1.3
5	Triose phosphate isomerase	+7.6	+2.5
6	Glyceraldehyde-3-phosphate dehydrogenase	+12.6	-3.4
7	Phosphoglycerate kinase	-37.6	+2.6
8	Phosphoglycerate mutase	+8.8	+1.6
9	Enolase	+3.4	-6.6
10	Pyruvate kinase	-62.8	-33.4

The DG values are estimated from intracellular concentrations of glycolytic intermediates in rabbit skeletal muscle. N.B., the DG values after reaction number 5 are doubled since two G-3-P molecules exist after reaction number 5. (Mathews p.459)


	[The Metabolic Pathways of Biochemistry] - [Copyright © 1998 Karl J. Miller.]

Glycolysis & Gluconeogenesis

Overall Reaction for the Pathway

Gibbs Free Energy Changes