The McCormick Genomics Center has helped to identify the potential targets of BP1, an important oncogene discovered in Dr. Berg’s lab in GW, which may play a role in breast and hematologic neoplasias.
The MGC has analyzed the microarray data for Dr. Sidney Fu's breast cancer research project funded by NIH.
The MGC has assisted in the design and execution of microarray analysis of the progression of breast cancer in minorities in studies conducted by Dr. Poola at Howard University. These studies are defining gene expression patterns associated with the highly aggressive forms of breast cancer observed in African-Americans.
The MGC is providing support in the design and execution of studies in animal models of melanoma by Dr. Noonan and Dr. De Fabo. These studies could provide valuable insight into the mechanisms of UV-induced skin cancer.

The MGC, through its Microarray Core, is helping to uncover the molecular basis of cardiovascular disease by analyzing mRNA expression profiles of cells derived from human atherosclerotic lesions, in studies from Dr. McCaffrey’s lab. Further, the behavior of these cells in response to stimulants and inhibitors with clinical relevance, such as rapamycin and flavopiridol, is providing important insight into the mechansisms of disease, and revealing new drug targets.

In collaboration with Dr. Valerie Hu and Dr. John Quackenbush, the MGC is participating in studies to identify the molecular defects associated with particular forms of childhood autism, such as Asperger’s syndrome. Using cell lines derived from affected children, and unaffected siblings, microarray technology will be used to identify genes that may be responsible.