Until approximately the year 2000, biomedical research,
and related genetic-based fields, identified genes on an ‘as needed’
basis, whereby a disease was loosely associated with, or “linked”,
to particular parts of a chromosome. These “linkage” studies are
still an important aspect of research because the distribution of genes and
diseases, particularly in the inheritance pattern of families, is a crucial
aspect of understanding the genetics of the disease More...
Before
the McCormick Genomics Center (MGC)
was established, the field of genomics was practiced by scientists in disparate
departments in GW (including biochemistry, pharmacology, immunology, microbiology,
computer science, biology, anthropology, and engineering). More...
LOLA
(List of Lists-Annotated) is a database
for annotation and comparison of published microarray gene lists developed by
the MGC (www.lola.gwu.edu). LOLA is used to analyze microarray
data on significant subsets of genes found in the published literatures.
The McCormick
Genomics Center has assisted in the design and execution of
microarray analysis of the progression of variety of cancers for a number of faculty members from GWU and other institutions..
The
Affymetrix GeneChip Microarray Technology is a powerful tool allowing
for unparalleled advances in gene discovery and molecular diagnosis. The MGC
at The George Washington University Medical Center provides a centralized facility
for large-scale transcript profiling using oligonucleotide microarrays (Affymetrix).
