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Genomics Server running Linux on a dual 2.4GHz processor with 4GB of RAM that supports the analysis, storage and distribution of functional genomics data.
Access to grid-based distributed processing for large-scale, parallel-processing problems.
64-node super-computing cluster. The MGC is a component of the GW Supercomputing cluster which is currently under construction.

Affymetrix GCOS 1.4 Software is used to acquire the array data via control of the Fluidics Station 450 and the GeneChip Scanner 3000. The acquired data is deconvolved into numerical expression levels which are further processed to compute normalized expression levels of each gene, and make present/absent calls based on the signal level of probes to paired control probes. The GCOS can be accessed via www.affymetrix.com.

Ingenuity Pathways Analysis (IPA 5.0) enables us to model, analyze and understand the complex biological systems from the vast amount of genomics and proteomics data. Ingenuity Pathways Analysis leverages the world largest knowledge base of biological networks, powerful algorithms and an easy-to-use software interface to provide researchers with the insights and confidence to make better and faster decisions at every step of our research. The MGC has a subscription to access and use this invaluble online software. You may access and use it via www.ingenuity.com with a valid user ID and password from the MGC.

LOLA (List of Lists-Annotated) is a database for annotation and comparison of published microarray gene lists developed by the MGC (http://www.lola.gwu.edu). LOLA is used to analyze microarray data on significant subsets of genes found in the published literature. It serves as a common platform to compare and reannotate heterogeneous gene lists from different platforms. LOLA provides researchers with a reliable, easily accessible and automated means to compare microarray data while simultaneously archiving and linking the data to published literature. LOLA is valuable tool for validating the results of microarray-based studies.

Protein Lounge has many interactive web-based databases and software to help understand the cellular networks, protein interactions involved in cell signaling, mechanisms of cell survival and apoptosis. Protein Lounge contains a complete siRNA target database, a complete Peptide-Antigen target database and a Kinase-Phosphatase database. It is an ideal site for both life-science researchers as well as students. The MGC has a subscription and can be accessed via www.proteinlounge.com.

ABI PRISM 7000 and 7300 Sequence Detection Systems are used in verifying microarray data, genotyping SNPs, and detecting microRNAs. There are more than 350,000 pre-designed, gene-specific TaqMan® probe and primer sets for quantitative gene expression studies of human, mouse, and rat genes. The real-time PCR assays and data analysis are performed using the Sequence Detection System 1.1 software. Primer Express 2.0 (ABI) is used for designing customized primers and TaqMan probes.

The GW Cluster will interlace 64 separate processors via high-speed buses to approach genomic problems requiring massively parallel computing.

GeneSpring GX is widely regarded as the gold standard for expression data analysis. GeneSpring is truly a cutting-edge tool for expression analysis, which has been used by thousands of elite scientists worldwide who depend on its sophisticated analysis techniques to advance their research. Designed to meet the needs of the individual researcher, GeneSpring seamlessly interfaces with Silicon Genetics’ Signet software, which provides a highly scalable platform for enterprise-level genomic research. The MGC has a dynamic license subscription to use it. You may download the software from www.agilent.com and request access from the MGC.