From the North:

Take I-95 south to 495 West (this is the Capitol Beltway). Sign will say 'Bethesda'
 
To get to DuPont Circle Hotels:
Take the Connecticut Avenue Exit (# ???) and go south all the way to DuPont Circle. This is several miles, but very easy and straight-forward.
 
To get to Arlington (i.e. our place or the Hilton):
495 West to Exit 43-44: George Washington Parkway (south). Caution- two exits share an off-ramp. Stay right for GW Parkway!
Take the I-66 E/US-50 exit towards ROOSEVELT BRIDGE/WASHINGTON/ROSSLYN. (~9 miles from when you get on)
Stay Right and merge on to Route 50 West.
Take the first exit (north Lynn St), Right at end of ramp.
Get in the LEFT lane ASAP.
At the second stoplight, make left on to Wilson Blvd- NOTE there is a little merge to make the left hand turn- all traffic except this left most lane will be going straight. Almost looks like an exit ramp. White mission/victorian style steak house in front of you while making left. After you make left- Hyatt will be on your right.
 
Proceed on Wilson 2-3 lights. Park where you can- We are at 1859 Wilson Blvd- across from Rhodeside Grill, near bus stop. Corner of Rhodes and Wilson.
 
To bypass us and go right to the Hilton- continue on Wilson Blvd. for ~2 block and make a left on Courthouse Road (first light up from our place). The Hilton is in a few blocks on the left.
 
Of note:
 
I. We have made this trip MANY times and there are ALWAYS problems on the New Jersey Turnpike. One trick is to cross over to 295 in central New Jersey and rejoin 95 at the Delaware Memorial Bridge.
II. When you come down Connecticut Ave., you will have the option of going UNDER DuPont Circle (via center lanes). Do not do this- get right as you approach the circle and then loop around to your desired location. If you do find yourself going under the circle- no biggie. You can turn around once out the other side.
 

From the South:

There are two routes if coming from the South. The first one listed is preferred for Alabama/Georgia residents, whereas #2 is better for southern Virginia and eastern Carolinas.
 
1. Take I-85 North to I-77 North (in Charlotte, NC).
Take 77N to I-81N (southwestern VA- no town of note)
81N to I-66 East (Front Royal, VA)
 
To our place and the Hilton:
 
To the DuPont Circle Hotels:
I-66 East to the Theodore Roosevelt Bridge (no exit for this- you will simply go over it and thus enter DC proper).
Once over the bridge, you are now on Consitution Ave (Welcome to our Nation's Capitol!).
Continue East on Constitution and make a Left on 17th Street. (Beware that 17 goes right past the White House and is sometime subject to random detours).
17th St. will make a slight jog where you get on Connecticut Ave.
Take Conn. Ave to DuPont Circle- stay right to avoid going UNDER the circle (see II, above).
Loop around the circle until you get to desired street- New Hampshire for Jury's and reception site, Massachusetts for the Westin.
Be careful here: if you come up Conn, you want to go all the way around to Mass Ave. This is a traffic circle and thus you would be going in the wrong direction if you take the first occurrence of Mass ave. Refer to the map on the preceding page.
 
2. Take 95 North to 395 North into downtown DC.