MOLECULAR MEDICINE
N.H. Lee (Director), M. Batshaw, P. Berg, L. Caldovic, S. Ceryak, V.A. Chiappinelli, A. Chiaramello, A. Colberg-Poley, M. Colonnese, J. Corbin, E.C. DeFabo, G. Dimri, S. Dopkins, S.W. Fu, V. Gallo, A.L. Goldstein, Y. Hathout, R. Hawley, T. Haydar, E. Hoffman, V. Hu, J. Jaiswal, K.A. Kennedy, J.M. Krum, A. Kumar, S. Ladisch, P. Latham, C.W. Linebaugh, T. McCaffrey, D. Mendelowitz, S.A. Moody, H. Morizono, J. Nazarian, T. O'Brien, R.K. Packer, T. Partridge, S.R. Patierno, D.C. Perry, K.D. Peusner, J. Philbeck, D. Reiss, M.C. Rose, J.M. Rosenstein, L.A. Rothblat, N. Sarvazyan, M.A. Stepp, A. Vandervere, L.L. Werling, I. Zohn
Doctor of Philosophy in the field of molecular medicine-Prerequisite: A bachelor's degree in chemistry, biological sciences, or an approved related field.
Required: the general requirements stated under Columbian College of Arts and Sciences. Course work must include the biomedical sciences core curriculum, with MMed 8214 and one of the following: Anat/Idis 6212, Phar 6205, or MMed 8221. Pertinent electives include MMed 8280, 8222, 8282; Bioc 6250; BiSc 6249, 6274, 6275; Psyc 8268 or 8281.
Research fields: neuroscience-neural transplantation, molecular mechanisms of action of drugs of abuse, neurotransmitter systems, developmental neurobiology, psychobiology of learning and memory, function of ion channels and receptors; oncology-cancer chemotherapy and mechanisms of resistance, UV light, tumor cell biology and metabolism, gene regulation, oncogenes and tumor suppressor genes, growth factors, chemotherapy and mechanisms of resistance, immunotherapy, development of immunological and molecular markers for diagnosis and detection, tumor immunology, epidemiology and prevention, cancer and AIDS, mechanisms of metastasis, transgenic models of cancer, genomics and proteomics; pharmacology-molecular carcinogenesis, genetic toxicology, cancer chemotherapy, neuropharmacology, biochemical and molecular pharmacology and toxicology.
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8214 |
Molecular Medicine Seminar (2) |
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Research topics in molecular medicine, including cellular and behavioral neuroscience, pharmacology, physiology, and pathophysiology. May be repeated for credit. Prerequisite: BmSc 8210, 8212, and consent of instructor.
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8221 |
The Basic Science of Oncology (3) |
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Epidemiology, genetics, viruses, oncogenes, chemical carcinogenesis, radiation carcinogenesis, tumor growth, metastasis, biochemistry of cancer cells, tumor markers, hormones and cancer, cancer immunobiology, radiotherapy, chemotherapy and immunotherapy.
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8222 |
Molecular Oncology (2) |
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Seminar course dealing with molecular basis for the topics introduced in MMed 8221.
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8230 |
Molecular Basis of Human Disease (3) |
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Principles of systems biology in the context of specific diseases. Problem solving at multiple levels of biology, integrating knowledge of DNA, RNA, proteins, cell biology, and tissue physiology. Prerequisite: BmSc 8210, 8212.
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8231 |
Advanced Proteomics Methods and Applications (2)
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Proteomics approaches to specific questions about a biological system. Advanced methods and applications. Prerequisite: MMed 8230.
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8232 |
Integrative Approaches to Biomedicine (2) |
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Integrated network approaches for accurate disease classification, diagnosis, and prognosis prediction; identification of novel therapeutic targets; determination of appropriate dosing. Prerequisite: MMed 8230.
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8233 |
Integrative Bioinformatics (2) |
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Bioinformatics techniques for analysis of macromolecular sequences, structures, gene expression arrays, and proteomics. Systems biology approaches to research problems. Prerequisite: MMed 8230.
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8280 |
Neurophysiology and Neuropharmacology (3) |
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Basic principles of electrophysiology and electrophysiological techniques. Basic principles of neuropharmacology, including neurobiological basis for mental health and disease.
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8282 |
Neural Development and Neurodevelopmental Disorders (3)
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Basic concepts of neural development, especially of the cerebral cortex, and their relevance to understanding the pathophysiology of neurodevelopmental disorders.
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8998 |
Advanced Reading and Research (arr.) |
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Limited to students preparing for the Doctor of Philosophy general examination. May be repeated for credit.
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8999 |
Dissertation Research (arr.) |
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Limited to Doctor of Philosophy candidates. May be repeated for credit.
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