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Education: B.S. in Biology, Cornell College, 1970 Ph.D. in Biology, University of Chicago, 1975 Research Interests: In recent years my research interests have focused on gene function
in Drosophila. The publication of the genome sequence of Drosophila
melanogaster has allowed the identification of gene families and
has simplified the processes needed to identify the sequences of
genes with detectable phenotypic effects. Early in my career I studied genetic variation in populatons. I was particularly interested in differentiation associated with speciation. More recently I have returned to the area of population diversity. My lab has been involved in general studies of genetic variation including mtDNA variation in man. In the last year my lab has been involved in molecular mapping of
genes responsible for visibly mutant phenotypes in Drosophila. We
have a particular interest in the genes that relate to eye color
as this is an opportunity to study in detail the types of genes
involved in producing a morphological character. Eye color in Drosophila
is a complex trait influenced by genes of many different types.
The Drosophila eye has two classes of pigments contained in it,
ommochromes and pteridines. Many of the genes involved in synthesis
of these pigments have already been identified. However, eye color
does not depend solely on the synthesis of the pigments. It has
been demonstrated that three genes involved in producing ABC transporters,
white, brown, and scarlet are involved in the transport of pigment
precursors to the eye. We are currently investigating a small gene family in Drosophila. We are characterizing gene expression patterns for the members of the family with respect to development. We are also studying the evolutionary relationships between members of the family. Finally we are characterizing specific activities of one of the genes.
Courses: Undergraduate: Bisc 107 - Genetics, Fall BiSc 108 - Genetics Laboratory, Spring BiSc 175 - Independent Study in Genetics and Evolutionary Biology, Fall and Spring, with permission Graduate: BiSc 227 -Seminar in Genetics, Fall, odd years BiSc 228 -Population Genetics, Fall, even years Gnet 201 -Advanced Problems in Genetics, Fall Gnet 301 -Advanced Problems in Genetics, Fall INFORMATION ABOUT DROSOPHILA AND DROSOPHILA GENETICS Flybase A database containing information about Drosophila Berkeley Drosophila Genome Project An introduction to Drosophila melanogaster TOOLS FOR ANALYSIS OF MOLECULAR
DATA POPULATION
BIOLOGY SIMULATIONS FROM THE UNIVERSITY OF CONNECTICUT GRADUATE EDUCATION IN GENETICS
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